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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1991-1-29
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pubmed:abstractText |
Effects of UV on normal human epidermal keratinocytes were studied by measuring the intracellular free Ca2+ concentration ([Ca2+]i) using fluorescence ratio imaging (fura-2-AM). Upon UV irradiation the [Ca2+]i increased sharply after a certain lag time, and the UV sensitivity was higher at lower temperatures. Statistically the distribution of [Ca2+]i became broader as the mean values became larger, and the number of affected cells increased sharply above a certain fluence (light intensity x time [photons/cm2]) at all wavelengths studied (200-400 nm). The action spectrum showed a single peak at about 230 nm and decreased gradually toward longer-wavelength UV regions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0386-7196
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2257637-Calcium,
pubmed-meshheading:2257637-Cells, Cultured,
pubmed-meshheading:2257637-Cytoplasm,
pubmed-meshheading:2257637-Fura-2,
pubmed-meshheading:2257637-Humans,
pubmed-meshheading:2257637-Keratinocytes,
pubmed-meshheading:2257637-Radiation Tolerance,
pubmed-meshheading:2257637-Spectrum Analysis,
pubmed-meshheading:2257637-Temperature,
pubmed-meshheading:2257637-Time Factors,
pubmed-meshheading:2257637-Ultraviolet Rays
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pubmed:year |
1990
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pubmed:articleTitle |
Ultraviolet action spectrum for intracellular free Ca2+ increase in human epidermal keratinocytes.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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