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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1991-1-24
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|
pubmed:abstractText |
A new mouse monoclonal antibody that recognizes alpha- and beta-heavy chains of human atrial and ventricular myosin and beta-heavy chain of human slow skeletal muscle myosin was obtained. The 125I- and 111In-labelled antibody, and its F(ab')2 and Fab fragments localize in isoproterenol induced infarcted rat heart, with the F(ab')2 fragment showing the highest uptake. Comparison with 99Tc-pyrophosphate uptake in infarcted dog heart, induced by selective obstruction of a coronary artery, suggest that the 111In-labelled F(ab')2 localizes specifically in infarcted myocardium only.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0883-2897
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
567-84
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|
pubmed:dateRevised |
2008-2-21
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|
pubmed:meshHeading |
pubmed-meshheading:2254094-Animals,
pubmed-meshheading:2254094-Antibodies, Monoclonal,
pubmed-meshheading:2254094-Dogs,
pubmed-meshheading:2254094-Female,
pubmed-meshheading:2254094-Immunoglobulin Fab Fragments,
pubmed-meshheading:2254094-Indium Radioisotopes,
pubmed-meshheading:2254094-Iodine Radioisotopes,
pubmed-meshheading:2254094-Myocardial Infarction,
pubmed-meshheading:2254094-Organometallic Compounds,
pubmed-meshheading:2254094-Rats,
pubmed-meshheading:2254094-Rats, Inbred Strains,
pubmed-meshheading:2254094-Tissue Distribution
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models.
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|
pubmed:affiliation |
Rougier Bio-Tech Ltd., Montreal, Quebec, Canada.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
