Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1990-12-31
|
| pubmed:abstractText |
Previous studies using classical cytogenetics have demonstrated the presence of the t(11;14) (q13;q32) chromosomal translocation in some cases of lymphocytic lymphoma of intermediate differentiation (IDL), a distinct type of low grade B-cell lymphoma. This finding suggested that the bcl-1 region (located at band q13 of chromosome 11) might be involved in this neoplasm. Using a genomic probe from the major breakpoint area of the bcl-1 locus, we identified rearrangements of the bcl-1 region in 10 of 19 cases, 2 of which comigrated with a rearranged allele of the immunoglobulin heavy chain gene joining region. In contrast, bcl-1 rearrangements were not found in other types of low grade B-cell lymphoma, specifically in 36 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and 27 cases of follicular lymphoma (FL). To further assess the molecular pathology of IDL, we analyzed these cases for rearrangements of the bcl-2 proto-oncogene, which is associated primarily with follicular lymphomas. None of the 19 cases of IDL had rearrangements. Furthermore, none of the 36 cases of CLL/SLL showed bcl-2 rearrangements, whereas, as expected, 21 of 27 cases of FL had rearrangements of the bcl-2 locus. Our findings demonstrate an association between a rearranged bcl-1 region with approximately 50% of IDLs and suggest that abnormalities of this locus may be important in the pathogenesis of IDL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
76
|
| pubmed:geneSymbol |
bcl-1,
bcl-2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2086-90
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2242428-Adult,
pubmed-meshheading:2242428-Aged,
pubmed-meshheading:2242428-Cell Transformation, Neoplastic,
pubmed-meshheading:2242428-Chromosome Mapping,
pubmed-meshheading:2242428-Chromosomes, Human, Pair 11,
pubmed-meshheading:2242428-Cyclin D1,
pubmed-meshheading:2242428-Female,
pubmed-meshheading:2242428-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:2242428-Genotype,
pubmed-meshheading:2242428-Humans,
pubmed-meshheading:2242428-Immunophenotyping,
pubmed-meshheading:2242428-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:2242428-Lymphoma, B-Cell,
pubmed-meshheading:2242428-Lymphoma, Non-Hodgkin,
pubmed-meshheading:2242428-Male,
pubmed-meshheading:2242428-Middle Aged,
pubmed-meshheading:2242428-Proto-Oncogene Proteins,
pubmed-meshheading:2242428-Proto-Oncogene Proteins c-bcl-2
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Association of bcl-1 rearrangements with lymphocytic lymphoma of intermediate differentiation.
|
| pubmed:affiliation |
Hematopathology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|