Linked Life Data

2241095

Source:http://linkedlifedata.com/resource/pubmed/id/2241095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5A
pubmed:dateCreated
1990-12-4
pubmed:abstractText
Malignant human glioma is characterized by an uncontrolled cell proliferation and infiltrative growth into the brain. The mechanisms by which invasion occurs are poorly understood. Due to recent development in tissue culture methods, it is possible to study invasion in organotypic coculture systems consisting of glioma spheroids and reaggregated fetal brain cells. Spheroids from well-characterized continuous human glioma cell lines have been tested for invasiveness in this model, which also allows studies of the invasive capacity of glioma cells derived from biopsy material within a week after surgery. Invasion may furthermore be studied in chemically defined media. The methods of studying in vitro glioma invasiveness are reviewed, together with recent results which may throw light upon important mechanisms related to glioma invasion, at the peri- and extracellular level. Mechanisms of glioma cell invasion are discussed with emphasis on the interactive process between cells, growth factors, proteolytic enzymes and the extracellular matrix.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1135-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Invasive glioma cells in tissue culture.
pubmed:affiliation
Department of Pathology, Haukeland Hospital, University of Bergen, Norway.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't