|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1990-12-26
|
|
pubmed:abstractText |
The mechanism of bowel obstruction in colorectal cancer is likely to involve interactions between tumour cells, host fibroblasts and the extracellular matrix. The role of fibroblast-mediated matrix reorganisation in malignant structures of the large bowel was examined in an in vitro collagen matrix model in which tumour cells and fibroblasts were cultured under serum-free conditions. Colon cancer cells secreted a factor(s) which enhanced the ability of colon fibroblasts to contrast a collagen matrix without an associated mitogenic response by the fibroblasts. Within uncontracted collagen gels marked elongation of fibroblast cell processes was observed in the presence of the tumour-derived factor(s). We propose that matrix reorganisation by host fibroblasts in the wall of the human colon is responsible, at least in part, for malignant large bowel obstruction.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-2298242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-2430714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-2592298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-2730461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-2731959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-286310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-2876336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3002610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3058520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3058521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3318882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3652004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3697935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3721406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3914484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3986481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-3997882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-4001590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-4041728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-4341725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-521466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-6235235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-6863399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-7107648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-7109538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-7419598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2223573-7448770
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0007-0920
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
62
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
567-72
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2223573-Cell Communication,
pubmed-meshheading:2223573-Cell Division,
pubmed-meshheading:2223573-Collagen,
pubmed-meshheading:2223573-Colon,
pubmed-meshheading:2223573-Colorectal Neoplasms,
pubmed-meshheading:2223573-Extracellular Matrix,
pubmed-meshheading:2223573-Fibroblasts,
pubmed-meshheading:2223573-Humans,
pubmed-meshheading:2223573-Intestinal Obstruction,
pubmed-meshheading:2223573-Models, Biological
|
|
pubmed:year |
1990
|
|
pubmed:articleTitle |
The role of colon fibroblasts in malignant large bowel obstruction--an experimental in vitro model.
|
|
pubmed:affiliation |
Discipline of Surgical Science, Faculty of Medicine, University of Newcastle, New South Wales, Australia.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
