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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-11-9
|
| pubmed:abstractText |
The relationship between prolonged exercise, oxidative stress, and the protective capacity of the antioxidant defense system has been determined. Venous blood samples were removed from seven trained athletes before and up to 120 h after completion of a half-marathon for measurements of blood antioxidants, antioxidant enzymes, and indices of lipid peroxidation. Plasma creatine kinase (CK) activity, an index of muscle damage, increased (P less than 0.05) to a maximum 24 h after the race but this was not accompanied by changes in conjugated dienes and thiobarbituric acid reactive substances (TBARS), which are indices of lipid peroxidation. An increase (P less than 0.05) in plasma cholesterol concentration (4%) immediately after the race was similar to the change in plasma volume (6%). However, transient increases (P less than 0.05) immediately postrace in the plasma concentrations of uric acid (24%), vitamin A (18%), and vitamin C (34%) were only partly accounted for by the fluid shifts. The immediate postrace increases in alpha- and gamma-tocopherol did not attain statistical significance. Erythrocyte antioxidant enzyme activities were unaffected by the exercise but the alpha- and gamma-tocopherol concentrations progressively increased (P less than 0.001 and P less than 0.05, respectively) up to 48 h postrace. Paradoxically, 24 h after the race erythrocyte susceptibility to in vitro peroxidation was markedly elevated (P less than 0.01). This enhanced susceptibility to peroxidation was maintained even at 120 h postrace and did not correspond to changes in the age of the red cell population. A decrease (P less than 0.001) in total erythrocyte glutathione immediately after the half-marathon was mainly due to a reduction in the reduced form (GSH). The results show that when trained athletes run a comparatively short distance sufficient to result in some degree of muscle damage but which is insufficient to cause elevations in plasma indices of lipid peroxidation, significant alterations in erythrocyte antioxidant status do occur.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Creatine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosephosphate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin A,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0003-9861
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
282
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
78-83
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:2221920-Adult,
pubmed-meshheading:2221920-Antioxidants,
pubmed-meshheading:2221920-Ascorbic Acid,
pubmed-meshheading:2221920-Catalase,
pubmed-meshheading:2221920-Cholesterol,
pubmed-meshheading:2221920-Creatine Kinase,
pubmed-meshheading:2221920-Erythrocytes,
pubmed-meshheading:2221920-Glucosephosphate Dehydrogenase,
pubmed-meshheading:2221920-Glutathione,
pubmed-meshheading:2221920-Glutathione Peroxidase,
pubmed-meshheading:2221920-Hemoglobins,
pubmed-meshheading:2221920-Humans,
pubmed-meshheading:2221920-Lipid Peroxidation,
pubmed-meshheading:2221920-Male,
pubmed-meshheading:2221920-Physical Exertion,
pubmed-meshheading:2221920-Physical Fitness,
pubmed-meshheading:2221920-Plasma Volume,
pubmed-meshheading:2221920-Running,
pubmed-meshheading:2221920-Superoxide Dismutase,
pubmed-meshheading:2221920-Vitamin A,
pubmed-meshheading:2221920-Vitamin E
|
| pubmed:year |
1990
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| pubmed:articleTitle |
Blood antioxidant status and erythrocyte lipid peroxidation following distance running.
|
| pubmed:affiliation |
Biochemistry Division, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.
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| pubmed:publicationType |
Journal Article
|