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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1990-11-19
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pubmed:abstractText |
1. The effects of intracisternal (i.c.) application of putative 5-hydroxytryptamine (5-HT)1A antagonists on the reflex bradycardia evoked by injection of phenylbiguanide (i.v.) were investigated in anaesthetized, atenolol-pretreated rats. 2. Intracisternal application of spiperone (100 micrograms kg-1) reversibly attenuated the reflex bradycardia whilst the same dose given i.v. had no effect. The bradycardia was also attenuated by i.c. methiothepin (200 micrograms kg-1), (+/-)-pindolol (100 micrograms kg-1) and buspirone (200 micrograms kg-1) but was not attenuated by antagonists selective for alpha 1-adrenoceptors (alfuzosin; 100 micrograms kg-1), 5-HT2-receptors (BW 501C67; 100 micrograms kg-1) or dopamine D2-receptors ((-)-sulpiride; 100 micrograms kg-1) given i.c. 3. It is concluded that the 5-HT1A-receptor antagonist action of intracisternally applied spiperone, methiothepin, (+/-)-pindolol and buspirone is responsible for the ability of these drugs to attenuate reversibly the excitation of cardiac vagal motoneurones caused by activation of the von Bezold-Jarisch reflex.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-14074564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-15405470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-17076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-2559349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-2611520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-2853614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-2933110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-2952887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-2957220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3006858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3161997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3207999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3215269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3290473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3505364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-39524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-3957952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-4052776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-4052777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-457932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-5420115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-6182416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-6390056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-6759990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-7017455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2207497-7174893
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
757-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2207497-Anesthesia,
pubmed-meshheading:2207497-Animals,
pubmed-meshheading:2207497-Atenolol,
pubmed-meshheading:2207497-Biguanides,
pubmed-meshheading:2207497-Blood Pressure,
pubmed-meshheading:2207497-Drug Interactions,
pubmed-meshheading:2207497-Heart,
pubmed-meshheading:2207497-Heart Rate,
pubmed-meshheading:2207497-Male,
pubmed-meshheading:2207497-Rats,
pubmed-meshheading:2207497-Rats, Inbred Strains,
pubmed-meshheading:2207497-Receptors, Serotonin,
pubmed-meshheading:2207497-Reflex
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pubmed:year |
1990
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pubmed:articleTitle |
Evidence that central 5-HT1A-receptors play a role in the von Bezold-Jarisch reflex in the rat.
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pubmed:affiliation |
Academic Department of Pharmacology, Royal Free Hospital School of Medicine, Hampstead, London.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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