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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
1990-11-20
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pubmed:databankReference |
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pubmed:abstractText |
We present a new protein from X. laevis skin termed "frog integumentary mucin B.1" (FIM-B.1) with a general structure similar to FIM-A.1 (formerly "spasmolysin"). The central region consisting of tandem repeats of 11 amino acid residues is probably a target for extensive O-glycosylation, whereas the C-terminal cysteine-rich domain shows pronounced homology with the C1-C2 domains and the C-terminal end of von Willebrand factor. Furthermore, we describe homology with antistasin, an anticoagulant peptide from a leech. We also discuss some implications concerning the evolutionary origin of von Willebrand factor. In situ hybridization studies revealed the expression of FIM-B.1 exclusively in mucous glands of the skin. This is comparable with FIM-A.1 but is in contrast to all other physiologically active peptides, which are synthesized in granular glands.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-2960
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6240-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2207068-Amino Acid Sequence,
pubmed-meshheading:2207068-Animals,
pubmed-meshheading:2207068-Base Sequence,
pubmed-meshheading:2207068-DNA,
pubmed-meshheading:2207068-Exocrine Glands,
pubmed-meshheading:2207068-Glycosylation,
pubmed-meshheading:2207068-Humans,
pubmed-meshheading:2207068-Invertebrate Hormones,
pubmed-meshheading:2207068-Leeches,
pubmed-meshheading:2207068-Molecular Sequence Data,
pubmed-meshheading:2207068-Mucins,
pubmed-meshheading:2207068-Mucus,
pubmed-meshheading:2207068-Protein Processing, Post-Translational,
pubmed-meshheading:2207068-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2207068-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2207068-Skin,
pubmed-meshheading:2207068-Xenopus Proteins,
pubmed-meshheading:2207068-Xenopus laevis,
pubmed-meshheading:2207068-von Willebrand Factor
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pubmed:year |
1990
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pubmed:articleTitle |
An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von Willebrand factor.
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pubmed:affiliation |
Max-Planck-Institut für Psychiatrie, Abteilung Neurochemie, Martinsried, FRG.
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pubmed:publicationType |
Journal Article,
Comparative Study
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