| pubmed-article:2203676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0123771 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2203676 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2203676 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2203676 | pubmed:dateCreated | 1990-10-11 | lld:pubmed |
| pubmed-article:2203676 | pubmed:abstractText | Since interleukin-2 (IL-2) and IL-4 act in concert to support the development of cytotoxic T lymphocytes (CTL) and the generation of antigen-specific tumour infiltrating lymphocytes (TIL), we investigated the interaction of these cytokines with an established TIL line. TIL proliferated in an additive fashion in response to suboptimal concentrations of IL-2 and various concentrations of IL-4. TIL possessed high-affinity IL-4 receptors whether cultured in recombinant IL-2 (rIL-2) or rIL-4, but cells cultured in rIL-2 had higher numbers of IL-4 receptors than cells cultured in rIL-4. When TIL were cultured in increasing concentrations of rIL-2, a dose-dependent enhancement in IL-4 receptor number was observed. The maximum induction of IL-4 receptor expression was achieved by 4 hr of incubation with rIL-2 and was completely blocked by cycloheximide. Other cytokines, such as rIL-1, recombinant tumour necrosis factor (rTNF), recombinant interferon-alpha (rIFN-alpha) and rIFN-gamma, had no effect on IL-4 receptor number. rIL-2 also up-regulated IL-4 receptors on CTLL-2, a murine CTL line. These data indicate that high-affinity IL-4 receptors exist on murine TIL and they can be up-regulated by IL-2. Our observation that IL-2 up-regulates IL-4 receptor may help explain the additive effects of these lymphokines on the proliferation of TIL and other cell lines. It may also help explain their co-operative effects on the generation of antigen-specific TIL and the differentiation of CTL. | lld:pubmed |
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| pubmed-article:2203676 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2203676 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2203676 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2203676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2203676 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2203676 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:2203676 | pubmed:author | pubmed-author:FinbloomD SDS | lld:pubmed |
| pubmed-article:2203676 | pubmed:author | pubmed-author:PuriR KRK | lld:pubmed |
| pubmed-article:2203676 | pubmed:author | pubmed-author:SiegelJ PJP | lld:pubmed |
| pubmed-article:2203676 | pubmed:author | pubmed-author:LelandPP | lld:pubmed |
| pubmed-article:2203676 | pubmed:author | pubmed-author:MostowskiHH | lld:pubmed |
| pubmed-article:2203676 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2203676 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:2203676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2203676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2203676 | pubmed:pagination | 492-7 | lld:pubmed |
| pubmed-article:2203676 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2203676 | pubmed:meshHeading | pubmed-meshheading:2203676-... | lld:pubmed |
| pubmed-article:2203676 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2203676 | pubmed:articleTitle | Expression of high-affinity IL-4 receptors on murine tumour infiltrating lymphocytes and their up-regulation by IL-2. | lld:pubmed |
| pubmed-article:2203676 | pubmed:affiliation | Division of Cytokine Biology, CBER/FDA, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:2203676 | pubmed:publicationType | Journal Article | lld:pubmed |
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