Linked Life Data

2201540

Source:http://linkedlifedata.com/resource/pubmed/id/2201540

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-9-26
pubmed:abstractText
Two 8-h primed continuous infusions of L-[1-13C] leucine were used to determine fractional synthesis rates of albumin and non-albumin plasma protein in post-absorptive Type I diabetic patients during insulin infusion and its withdrawal. Fractional protein synthetic rates were calculated from the rate of incorporation of 13C-label into protein and employing plasma 13C-alpha-ketoisocaproic acid enrichment to represent the precursor pools label. Incorporation of 13C into albumin and non-albumin plasma protein was linear over the latter 6 h of the 8-h L-[1-13C] leucine infusion. Fractional synthetic rates of plasma albumin and non-albumin proteins were similar during insulin withdrawal and its infusion. The increased whole-body protein synthesis observed during insulin withdrawal in Type I diabetic patients appears unrelated to events in albumin and non-albumin plasma protein fractions. These data are further evidence that insulin per se does not stimulate protein synthesis in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0954-3007
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Influence of insulin on albumin and non-albumin protein fractional synthetic rates in post-absorptive type I diabetic patients.
pubmed:affiliation
Nutrition Research Group, Clinical Research Centre, Harrow, Middlesex, UK.
pubmed:publicationType
Journal Article