| pubmed-article:2201176 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C0312860 | lld:lifeskim |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C0439852 | lld:lifeskim |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C1522428 | lld:lifeskim |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2201176 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2201176 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:2201176 | pubmed:dateCreated | 1990-9-14 | lld:pubmed |
| pubmed-article:2201176 | pubmed:abstractText | The alpha and beta forms of recombinant interleukin-1 (IL-1 alpha and IL-1 beta) and of recombinant Tumor Necrosis Factor (TNF alpha and TNF beta) induced dose-dependent neutrophil migration into rat peritoneal cavities. Migration induced by both IL-1s showed a bell-shaped dose-response curve and IL-1 beta was 3-fold more potent than IL-1 alpha. Pretreatment of the animals with dexamethasone or depletion of the peritoneal macrophage population, abolished the neutrophil migration induced by the four cytokines. "In vitro" stimulation of macrophage monolayers with IL-1 beta and the TNFs released a factor into the supernatant which, unlike these cytokines, induced neutrophil migration in dexamethasone pretreated animals. These results suggest that the neutrophil migration induced by IL-1 alpha, IL-1 beta, TNF alpha and TNF beta is not due to a direct effect on neutrophils, but occurs via the release of a chemotactic factor(s) from resident macrophages. | lld:pubmed |
| pubmed-article:2201176 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2201176 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2201176 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2201176 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2201176 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2201176 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2201176 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2201176 | pubmed:issn | 0065-4299 | lld:pubmed |
| pubmed-article:2201176 | pubmed:author | pubmed-author:FerreiraS HSH | lld:pubmed |
| pubmed-article:2201176 | pubmed:author | pubmed-author:PooleSS | lld:pubmed |
| pubmed-article:2201176 | pubmed:author | pubmed-author:CunhaF QFQ | lld:pubmed |
| pubmed-article:2201176 | pubmed:author | pubmed-author:FaccioliL HLH | lld:pubmed |
| pubmed-article:2201176 | pubmed:author | pubmed-author:SouzaG EGE | lld:pubmed |
| pubmed-article:2201176 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2201176 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:2201176 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2201176 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2201176 | pubmed:pagination | 344-9 | lld:pubmed |
| pubmed-article:2201176 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:2201176 | pubmed:meshHeading | pubmed-meshheading:2201176-... | lld:pubmed |
| pubmed-article:2201176 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2201176 | pubmed:articleTitle | Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration "in vivo" by indirect mechanisms. | lld:pubmed |
| pubmed-article:2201176 | pubmed:affiliation | Department of Pharmacology, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil. | lld:pubmed |
| pubmed-article:2201176 | pubmed:publicationType | Journal Article | lld:pubmed |
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