Linked Life Data

21937911

Source:http://linkedlifedata.com/resource/pubmed/id/21937911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2011-9-22
pubmed:abstractText
Simple and complex forms of dysembryoplastic neuroepithelial tumors (DNTs) are readily recognizable but forms with diffuse growth pattern, and hybrid tumors, that is, mixed DNT and ganglioglioma (DNT/GG), are more contentious entities. Rare DNTs have shown aggressive behavior. We reviewed cortical growth patterns, immunophenotype (including CD34, nestin and calbindin), genetic profile, and outcome in 101 DNT in adults. Simple (n = 18), complex (n = 31), diffuse (n = 35) DNT, and mixed DNT/GG (n = 17) showed no difference in age of onset, associated seizure type, or outcome (67.5% free from seizure; mean follow-up, 6 years). CD34 was seen in 61%, calbindin in 57%, and nestin in 86% of all DNT types; these markers were less common in simple DNT. Peritumoral cortical changes (Layer I hypercellularity [61%], satellite nodules [51.6%]) were frequent, but dyslamination (cortical dysplasia) was not identified. Molecular genetic abnormalities identified in 17 cases were IDH1 mutation (n = 3), 1p/19q loss (n = 10), isolated loss 9q (n = 2), and PTEN loss (n = 3), which were not associated with tumor type or location, higher cell proliferation, or distinguishing clinical features (mean age of epilepsy onset, 9 years; age at surgery = 31 years; 69% free from seizure); none had progression on magnetic resonance imaging (mean follow-up, 6 years). No single feature was predictive of seizure-free outcome, but there was a trend for better outcome in CD34-positive tumors (p = 0.07). One case has shown transformation to a higher grade. This study supports the existence of a range of subtypes of DNT some with overlapping features with ganglioglioma; molecular genetic abnormalities were not predictive of atypical behavior.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
859-78
pubmed:meshHeading
pubmed-meshheading:21937911-Adolescent, pubmed-meshheading:21937911-Adult, pubmed-meshheading:21937911-Age of Onset, pubmed-meshheading:21937911-Aged, pubmed-meshheading:21937911-Antigens, CD34, pubmed-meshheading:21937911-Cerebral Cortex, pubmed-meshheading:21937911-Child, pubmed-meshheading:21937911-DNA Mutational Analysis, pubmed-meshheading:21937911-Epilepsy, pubmed-meshheading:21937911-Female, pubmed-meshheading:21937911-Humans, pubmed-meshheading:21937911-Isocitrate Dehydrogenase, pubmed-meshheading:21937911-Longitudinal Studies, pubmed-meshheading:21937911-Magnetic Resonance Imaging, pubmed-meshheading:21937911-Male, pubmed-meshheading:21937911-Middle Aged, pubmed-meshheading:21937911-Mutation, pubmed-meshheading:21937911-Neoplasms, Neuroepithelial, pubmed-meshheading:21937911-Nerve Tissue Proteins, pubmed-meshheading:21937911-Oligodendroglia, pubmed-meshheading:21937911-Tomography, X-Ray Computed, pubmed-meshheading:21937911-Young Adult
pubmed:year
2011
pubmed:articleTitle
One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature.
pubmed:affiliation
Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK. MThom@ion.ucl.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't