Linked Life Data

2193595

Source:http://linkedlifedata.com/resource/pubmed/id/2193595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-7-31
pubmed:abstractText
Immunological parameters of porcine peripheral blood mononuclear cells after in vivo injections of human recombinant interleukin-2(125) (HrIL-2) were studied. Eighteen pigs (6 pigs/group) were injected with either 10(4) or 10(5) units/kg body weight of human rIL-2 or an equivalent volume of sterile physiological saline (control) on days 0 through 4. All pigs were immunized with an E coli J5 bacterin on day 0. Cytolytic activity to porcine fibroblasts (PK-15) was increased (P less than 0.02) in pigs treated with HrIL-2 when compared to control animals. Cytotoxicity to K-562 cells also showed a tendency (P less than 0.08) towards increased cytolytic activity in the HrIL-2-treated pigs. Lymphocyte blastogenesis, IL-2 production, and serum iron concentrations did not differ between treatment groups. Antibody concentrations to E coli J5 antigens increased significantly (P less than 0.05) in all groups after immunization, but there were no differences between treatment groups. These data suggest that in vivo injections of Hr-IL-2 increase natural cytotoxic cell activity in pigs without influencing other immune activities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4193
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Human recombinant interleukin-2 augments porcine natural killer cell cytotoxicity in vivo.
pubmed:affiliation
Department of Anatomy and Physiology, Kansas State University, Manhattan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't