Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-7-20
|
pubmed:abstractText |
To determine whether antiplatelet therapy following carotid bifurcation endarterectomy influences postoperative survival and whether signs of progression in the plaques harvested at the time of surgery might be a prognostic indicator, a controlled clinical trial was undertaken. During 1982 to 1985, 66 patients were recruited, operated on (carotid endarterectomy) and assigned, using the method of adaptive randomisation to the therapy group (n = 32) receiving 1.0 g acetylsalicylic acid (ASA) per day, starting day two prior to surgery, or to the control group (n = 34), which remained without antiplatelet medication. The plaques harvested at the time of surgery were processed using standard histopathological methods and examined "blindly" by light microscopy for signs of arterio-sclerotic progression. The final endpoint was patient survival. The last assessment of the participants survival status was done by June 1989. During follow-up, 20 patients died, six in the treatment group and 14 in the untreated group, the difference being statistically significant (P less than 0.013 Breslow, P less than 0.029 Mantel). In 27 instances the histo-pathological examination showed signs of progression. In this subgroup ASA yielded a significant prolongation of patient survival (P less than 0.017 Breslow, P less than 0.048 Mantel). In the remaining patients no signs of cellular infiltration were evident and no influence of ASA on patient survival was demonstrable (P less than 0.503 Breslow, P less than 0.390 Mantel).
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0950-821X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
4
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
285-9
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2191878-Aged,
pubmed-meshheading:2191878-Aspirin,
pubmed-meshheading:2191878-Carotid Arteries,
pubmed-meshheading:2191878-Carotid Artery Diseases,
pubmed-meshheading:2191878-Endarterectomy,
pubmed-meshheading:2191878-Female,
pubmed-meshheading:2191878-Follow-Up Studies,
pubmed-meshheading:2191878-Humans,
pubmed-meshheading:2191878-Intracranial Arteriosclerosis,
pubmed-meshheading:2191878-Male,
pubmed-meshheading:2191878-Middle Aged,
pubmed-meshheading:2191878-Postoperative Care,
pubmed-meshheading:2191878-Prospective Studies,
pubmed-meshheading:2191878-Randomized Controlled Trials as Topic,
pubmed-meshheading:2191878-Time Factors
|
pubmed:year |
1990
|
pubmed:articleTitle |
Antiplatelet therapy following carotid bifurcation endarterectomy. Evaluation of a controlled clinical trial. Prognostic significance of histologic plaque examination on behalf of survival.
|
pubmed:affiliation |
1st Clinic of Surgery, The University, Vienna, Austria.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|