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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-9-7
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pubmed:abstractText |
Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few metabolites that could be detected in plasma samples for about 3 hours. The absolute bioavailability of M-11 after oral administration was 68.3%. It was found that M-11 was completely absorbed from gastrointestinal tract of rats and characterized by "the first pass effect", after which approximately 70% of administered dose entered the circulation. The parent substance was determined neither in urine nor in feces.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0869-2092
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
22-6
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pubmed:meshHeading |
pubmed-meshheading:21894764-Animals,
pubmed-meshheading:21894764-Anti-Anxiety Agents,
pubmed-meshheading:21894764-Anxiety Disorders,
pubmed-meshheading:21894764-Area Under Curve,
pubmed-meshheading:21894764-Benzimidazoles,
pubmed-meshheading:21894764-Biological Availability,
pubmed-meshheading:21894764-Biotransformation,
pubmed-meshheading:21894764-Chromatography, Liquid,
pubmed-meshheading:21894764-Feces,
pubmed-meshheading:21894764-Gastrointestinal Tract,
pubmed-meshheading:21894764-Half-Life,
pubmed-meshheading:21894764-Infusions, Parenteral,
pubmed-meshheading:21894764-Injections, Intravenous,
pubmed-meshheading:21894764-Limit of Detection,
pubmed-meshheading:21894764-Male,
pubmed-meshheading:21894764-Morpholines,
pubmed-meshheading:21894764-Rats,
pubmed-meshheading:21894764-Tandem Mass Spectrometry
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pubmed:year |
2011
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pubmed:articleTitle |
[Pharmacokinetics of afobazole metabolite (M-11) in rats].
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pubmed:publicationType |
Journal Article,
English Abstract
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