Linked Life Data

21888224

Source:http://linkedlifedata.com/resource/pubmed/id/21888224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-9-5
pubmed:abstractText
Benz[a]anthracene is a ubiquitous environmental contaminant formed during the incomplete combustion of organic material. Some of the metabolites of benz[a]anthracene are known to be toxic and carcinogenic. In this investigation, benz[a]anthracene-induced oxidative damage to lymphocyte DNA was evaluated with the Comet assay (single cell gel electrophoresis). The level of oxidative DNA damage caused by benz[a]anthracene increased in a dose-dependent manner (24, 49) and oxidative DNA damage was significantly inhibited by 5 and 10 microg ml(-1) ascorbate, 5 microg ml(-1) polyphenols, as well as 5 and 10 microg ml(-1) curcumin. Moreover, traditional Korean medicinal herbs such as Acanthopanax and ginseng significantly reduced DNA damage. The results demonstrate that antioxidant supplementation to lymphocytes inhibits oxidative DNA damage in vitro, supporting an inhibitory effect against oxidative DNA damage, probably due to reduction of reactive oxygen species production induced by benz[a]anthracene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0254-8704
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-10
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Inhibitory effect of antioxidants on the benz[a]anthracene-induced oxidative DNA damage in lymphocyte.
pubmed:affiliation
Department of Medical Biotechnology, SoonChunHyang University, Asan, Chungnam - 336 600, Korea.
pubmed:publicationType
Journal Article