21886584

Source:http://linkedlifedata.com/resource/pubmed/id/21886584

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004083, umls-concept:C0025611, umls-concept:C0439857, umls-concept:C1335671
pubmed:issue	1
pubmed:dateCreated	2011-9-2
pubmed:abstractText	Several lines of evidence implicate serotonergic dysfunction in diverse psychiatric disorders including anxiety, depression, and drug abuse. Mice with a knock-out of the 5HT1b receptor gene (HTR1B) displayed increased locomotor response to cocaine and elevated motivation to self-administer cocaine and alcohol. Previous genetic studies showed significant associations of HTR1B with alcohol dependence and substance abuse, but were followed by inconsistent results. We examined a case-control genetic association study of HTR1B with methamphetamine-dependence patients in a Japanese population. The subjects were 231 patients with methamphetamine dependence, 214 of whom had a co-morbidity of methamphetamine psychosis, and 248 age- and sex-matched healthy controls. The three single nucleotide polymorphisms (SNPs), rs130058 (A-165T), rs1228814 (A-700C) and rs1228814 (A+1180G) of HTR1B were genotyped. There was no significant difference in allelic and genotypic distributions of the SNPs between methamphetamine dependence and the control. Genetic associations of HTR1B were tested with several clinical phenotypes of methamphetamine dependence and/or psychosis, such as age at first abuse, duration of latency from the first abuse to onset of psychosis, prognosis of psychosis after therapy, and complication of spontaneous relapse of psychotic state. There was, however, no asscocation between any SNP and the clinical phenotypes. Haplotype analyses showed the three SNPs examined were within linkage disequilibrium, which implied that the three SNPs covered the whole HTR1B, and distribution of estimated haplotype frequency was not different between the groups. The present findings may indicate that HTR1B does not play a major role in individual susceptibility to methamphetamine dependence or development of methamphetamine-induced psychosis.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-10334495, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-10550489, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-11104852, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-11496363, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-11751038, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-12496953, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-12898580, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-12931138, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-14593427, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-14714219, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-15527863, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-15542728, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-1604710, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-2315363, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-3007443, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-8209252, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-8782828, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-9603521, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-9819067, http://linkedlifedata.com/resource/pubmed/commentcorrection/21886584-9822762
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101157239
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Mar
pubmed:issn	1875-6190
pubmed:author	pubmed-author:InadaTT, pubmed-author:IwataNN, pubmed-author:KishimotoMM, pubmed-author:KodamaMM, pubmed-author:LuN MNM, pubmed-author:OkahisaYY, pubmed-author:OzakiNN, pubmed-author:REGOS FSF, pubmed-author:TakakiMM, pubmed-author:UchimuraNN, pubmed-author:UjikeHH, pubmed-author:YamadaMM
pubmed:issnType	Electronic
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	163-8
pubmed:year	2011
pubmed:articleTitle	Association Between 5HT1b Receptor Gene and Methamphetamine Dependence.
pubmed:affiliation	Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
pubmed:publicationType	Journal Article