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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-6-25
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pubmed:abstractText |
An Escherichia coli clone producing a high-molecular-weight surface antigen of Haemophilus influenzae type b (Hib) was isolated from a library of Hib DNA fragments cloned as lysogens in a lambda replacement vector. The antigen is found in sarcosyl-insoluble outer membrane protein preparations and was produced by all 36 H. influenzae isolates tested. Absorption studies indicated that the antigen is a surface determinant on all isolates tested. Antibodies to the antigen (D15) were found in eight of nine convalescent-phase sera from children with invasive Hib infection. Affinity-purified antibodies prepared against the cloned antigen gave protection against the development of bacteremia in a rat pup model.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2445684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2578121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2580914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2824380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2828309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2842261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2863681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-2887940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3257200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3262090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3294331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3489731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3499397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3519459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-3899933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-6147602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-6153662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2187812-6266278
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1909-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2187812-Animals,
pubmed-meshheading:2187812-Antibodies, Bacterial,
pubmed-meshheading:2187812-Antigens, Bacterial,
pubmed-meshheading:2187812-Antigens, Surface,
pubmed-meshheading:2187812-Bacterial Proteins,
pubmed-meshheading:2187812-Cloning, Molecular,
pubmed-meshheading:2187812-Escherichia coli,
pubmed-meshheading:2187812-Haemophilus influenzae,
pubmed-meshheading:2187812-Molecular Weight,
pubmed-meshheading:2187812-Rats,
pubmed-meshheading:2187812-Vaccines, Synthetic
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pubmed:year |
1990
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pubmed:articleTitle |
Expression in Escherichia coli of a high-molecular-weight protective surface antigen found in nontypeable and type b Haemophilus influenzae.
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pubmed:affiliation |
Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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