Linked Life Data

21869744

Source:http://linkedlifedata.com/resource/pubmed/id/21869744

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-8-26
pubmed:abstractText
Substantial progress in human leukocyte antigen antibody specification has been made by the introduction of Luminex single-antigen bead (SAB) assays. This progress was impaired when it turned out that this method is prone to a prozone effect leading to false-negative results in the case of high antibody titers. Testing serum and ethylenediaminetetraacetic acid (EDTA) plasma of one patient in parallel, we observed the prozone effect with the serum sample only. This led us to investigate complement component 1 (C1) as the cause of the prozone in SAB testing. We also found an easy way to overcome the prozone effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1534-6080
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
510-5
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
HLA antibody specification using single-antigen beads--a technical solution for the prozone effect.
pubmed:affiliation
Center for Clinical Transfusion Medicine, University Hospital of Tübingen, Otfried-Müller-Strasse 4/1, Tübingen, Germany. martina.schnaidt@med.uni-tuebingen.de
pubmed:publicationType
Journal Article, Evaluation Studies