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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-8-26
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pubmed:abstractText |
The phosphatidylinositol 3-kinase (PI3K)/protein kinase B(AKT)/mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in many types of cancer, including breast cancer. It is recognized that breast cancer cells develop resistance to a variety of standard therapies through the activation of this pathway. We hypothesized that targeting this signaling by the mTOR inhibitor RAD001 may potentiate the cytotoxicity of a conventional chemotherapeutic drug, carboplatin, and enhance the treatment efficacy for breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1791-7530
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2713-22
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pubmed:meshHeading |
pubmed-meshheading:21868512-Antineoplastic Agents,
pubmed-meshheading:21868512-Apoptosis,
pubmed-meshheading:21868512-Blotting, Western,
pubmed-meshheading:21868512-Breast Neoplasms,
pubmed-meshheading:21868512-Cell Cycle,
pubmed-meshheading:21868512-Cell Line, Tumor,
pubmed-meshheading:21868512-Drug Synergism,
pubmed-meshheading:21868512-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21868512-Female,
pubmed-meshheading:21868512-Flow Cytometry,
pubmed-meshheading:21868512-Genes, p53,
pubmed-meshheading:21868512-Humans,
pubmed-meshheading:21868512-Membrane Potentials,
pubmed-meshheading:21868512-Sirolimus,
pubmed-meshheading:21868512-TOR Serine-Threonine Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
The mTOR inhibitor RAD001 sensitizes tumor cells to the cytotoxic effect of carboplatin in breast cancer in vitro.
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pubmed:affiliation |
Division of Oncology and Hematology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. jan.eucker@charite.de and hongyu.liu@charite.de.
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pubmed:publicationType |
Journal Article
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