Linked Life Data

2184909

Source:http://linkedlifedata.com/resource/pubmed/id/2184909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-6-5
pubmed:abstractText
Since steroid therapy has been mostly utilized on an empirical basis in the management of head injury, this experimental study to assess the efficacy of steroid therapy was performed. Swiss-Webster mice (n = 85) were given 0.2 m of 50% ethanol intraperitoneally (IP) and lightly anaesthetized with ether. Ten randomly chosen mice were set aside and received no further treatment (non-head injury controls: Group A). The remaining mice (n = 75) were subjected to head injury and the survivors at 30 minutes (n = 52) were assigned randomly to two Groups, B and C. Group B was given 0.1 ml of saline IP at 30 minutes, 28 hours and 48 hours post-injury. At similar time intervals, animals in Group C received methylprednisolone 30 mg/kg IP. All animals were observed up to seven days and the number of survivors in each group recorded. All ten animals in Group A survived seven days. The daily mortality in Groups B and C were similar, and all animals were dead at seven days. Steroids were not found to be efficacious in this animals model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0269-9052
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-201
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Effect of steroid therapy in experimental head trauma.
pubmed:affiliation
Department of Surgery, UMDNJ-New Jersey Medical School, Newark 07103-2757.
pubmed:publicationType
Journal Article