Source:http://linkedlifedata.com/resource/pubmed/id/21829415
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2011-8-10
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| pubmed:abstractText |
A sclerosing stromal tumor of the ovary is an extremely rare benign tumor; it usually is found during the second and third decades of life. Patients present with pelvic pain or a palpable abdominal mass. Hormonal effects such as masculinization are uncommon. Here, an 11-year old premenarchal girl presented with deepening of the voice. In addition, clitoromegaly and hirsutism with a male suprapubic hair pattern were observed. The laboratory findings showed that the testosterone level was elevated to 3.67 ng/mL, andostenedione to above 10 ng/mL, dehydroepiandrosterone-sulfate to 346 µg/dL and 17-hydroxy progesterone (17-OHP) to 11.28 ng/mL. The chromosome evaluation revealed a 46,XX female karyotype. An adrenocorticotropic hormone stimulation test was performed. The 17-OHP to cortisol ratio in 30 minutes was 0.045, which suggested a heterozygote for the 21-hydroxylase deficiency. However, the CYP21A2 gene encoding steroid 21-hydroxylase showed normal. The pelvic ultrasound showed a heterogeneous mass consisting of predominantly solid tissue in the pelvic cavity. The pelvic magnetic resonance imaging revealed an 8.9×6.2×6.6 cm mass of the left ovary. A left oophrectomy was performed and microscopic examination confirmed a sclerosing stromal tumor. Immunohistochemical studies showed that the tumor was positive for smooth muscle actin and vimentin, but negative for S-100 protein and cytokeratin. Following surgery, the hormone levels returned to the normal range and the hirsutism resolved.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-12173003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-12497242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-15191104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-16403568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-1752500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-19283376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-2227841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-3383419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-4348335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-7236558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-9481554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21829415-9522851
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
2092-7258
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
224-7
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| pubmed:year |
2011
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| pubmed:articleTitle |
A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl.
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| pubmed:affiliation |
Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea.
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| pubmed:publicationType |
Journal Article
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