21811681

Source:http://linkedlifedata.com/resource/pubmed/id/21811681

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0030705, umls-concept:C0032285, umls-concept:C0085413, umls-concept:C2609414
pubmed:dateCreated	2011-8-3
pubmed:abstractText	Background. In animal models, polycystic kidneys are susceptible to acute kidney injury (AKI). We examined the occurrence of AKI in a cohort of autosomal dominant polycystic kidney disease (ADPKD) and non-ADPKD patients with acute pneumonia. Design. All ADPKD patients admitted to Mayo Clinic Rochester for pneumonia from January 1990 to April 2010 were examined. Sixty-three patients had lobar infiltration and consolidation on chest X-ray. After excluding patients on dialysis, with organ transplantation, and on chronic immunosuppression, 24 remaining ADPKD patients were enrolled. Twenty-three of the 24 were matched with 92 (1?:?4 ratio) non-ADPKD pneumonia patients based on their baseline eGFR. AKI was defined as serum creatinine elevation ?0.3?mg/dL. Results. Sixteen of the 23 ADPKD patients (69.6%) and 36 of the 92 (39.1%) non-ADPKD patients developed AKI, P = 0.008. In both groups, those who developed AKI had a lower baseline eGFR (41.1 ± 5.00 versus 58.7 ± 11.8 in ADPKD and 40.2 ± 3.65 versus 51.8 ± 2.24?mL/min/1.73?m(2) in the non-ADPKD group), more intensive care unit admissions, and longer hospital stays. AKI was associated with a reduced survival in both groups. Conclusions. Patients with ADPKD admitted for acute pneumonia had more frequent episodes of AKI than non-ADPKD patients with comparable kidney function.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-10075613, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-11979336, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-12728155, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-15312219, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-16707749, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-18520698, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-18633340, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-18832246, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-19342421, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-19729489, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-19833899, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-20032961, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-20219615, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-20435657, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-3599654, http://linkedlifedata.com/resource/pubmed/commentcorrection/21811681-7776989
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101546753
pubmed:status	PubMed-not-MEDLINE
pubmed:issn	2090-2158
pubmed:author	pubmed-author:Cartin-CebaRodrigoR, pubmed-author:Franco PalaciosCarlosC, pubmed-author:HartmanRobert PRP, pubmed-author:KeddisMira TMT, pubmed-author:LiGuangxiG, pubmed-author:QinDingxinD, pubmed-author:RIOU, pubmed-author:WangXianglingX, pubmed-author:ZandLadanL
pubmed:issnType	Electronic
pubmed:volume	2011
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	617904
pubmed:year	2011
pubmed:articleTitle	Acute Kidney Injury in ADPKD Patients with Pneumonia.
pubmed:affiliation	Division of Nephrology and Hypertension, Department of Medicine, Mayo Medical School, 200 First Street SW, Rochester, MN 55905, USA.
pubmed:publicationType	Journal Article