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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-8-1
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pubmed:abstractText |
We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/,
http://linkedlifedata.com/resource/pubmed/grant/DK089536,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM065400-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM095501,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM095501-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM095501-02,
http://linkedlifedata.com/resource/pubmed/grant/R01GM065400
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1879-1301
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pubmed:author |
pubmed-author:BeierKevin TKT,
pubmed-author:CepkoConstance LCL,
pubmed-author:CronicanJames JJJ,
pubmed-author:DavisTina NTN,
pubmed-author:KungAndrew LAL,
pubmed-author:LiWeidaW,
pubmed-author:LiuDavid RDR,
pubmed-author:MayErin MEM,
pubmed-author:ShihAllen FAF,
pubmed-author:ThompsonDavid BDB,
pubmed-author:TsengJen-ChiehJC,
pubmed-author:ZhouQiaoQ
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
833-8
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pubmed:meshHeading |
pubmed-meshheading:21802004-Adipose Tissue, White,
pubmed-meshheading:21802004-Animals,
pubmed-meshheading:21802004-Cell Line,
pubmed-meshheading:21802004-Cytosol,
pubmed-meshheading:21802004-Databases, Protein,
pubmed-meshheading:21802004-Humans,
pubmed-meshheading:21802004-Mice,
pubmed-meshheading:21802004-Models, Molecular,
pubmed-meshheading:21802004-Pancreas,
pubmed-meshheading:21802004-Protein Transport,
pubmed-meshheading:21802004-Proteins,
pubmed-meshheading:21802004-Recombinant Fusion Proteins,
pubmed-meshheading:21802004-Retina
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pubmed:year |
2011
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pubmed:articleTitle |
A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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