Linked Life Data

2179587

Source:http://linkedlifedata.com/resource/pubmed/id/2179587

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-4-20
pubmed:abstractText
To determine the influence of unrepaired technical defects as well as systemic risk factors for atherogenesis on carotid artery healing after endarterectomy, we conducted a prospective study using intraoperative duplex scanning with spectral analysis to establish the initial status of the artery (N = 131 arteries), and then we studied these vessels at regular postoperative intervals with the same technique (N = 108 arteries, 265 studies). The vessels were divided into the operated and nonoperated segments of the common, internal, and external carotid arteries, and both intraoperative image and flow data were tabulated by artery segment. The technical factors that were analyzed included defect size, defect type, adjacent segment defects, number of defects, shunt use, vessel reopening, and peak, mean, and end-diastolic frequency and velocity. The systemic risk factors studied were sex, hypertension, diabetes, smoking, randomly drawn total serum cholesterol and triglyceride levels, and perioperative aspirin and dextran use. Data were analyzed by linear logistic regression analysis. Among the technical factors, only intraoperative defect size was significantly associated with risk of recurrent stenosis (p = 0.0175). Although any defect size adversely affected the condition of the vessel during follow-up, the magnitude of this effect was small for smaller defects (size category 1: less than or equal to 40% stenosis or flap length less than or equal to 25% of vessel diameter). The systemic factors that were associated with risk of recurrent stenosis were hypertension (p = 0.0002), smoking (p = 0.0016), and randomly drawn total serum cholesterol level (p = 0.0116). The fact that the operated segments consistently fared worse during follow-up than did the nonoperated segments (p = 0.0044) undoubtedly reflects the inevitable trauma of the endarterectomy, but also emphasizes the important contribution of systemic risk factors in recurrent carotid stenosis. Risk factor modification may be the most effective method of ensuring the durability of carotid endarterectomy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0741-5214
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
448-59; discussion 459-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Recurrent carotid stenosis: a consequence of local or systemic factors? The influence of unrepaired technical defects.
pubmed:affiliation
Department of Surgery, University of California, San Francisco 94143.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't