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pubmed-article:21779359pubmed:abstractTextGraft-versus-host disease (GVHD) remains the main barrier to broader application of allogeneic hematopoietic stem cell transplantation (alloSCT) as a curative therapy for host malignancy. GVHD is mediated by allogeneic T cells directed against histocompatibility antigens expressed by host tissues. Based on previous studies, we postulated that the integrin CD103 is required for CD8-mediated GVHD, but not for graft-versus-tumor effects (GVT).lld:pubmed
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pubmed-article:21779359pubmed:articleTitleCD103 deficiency prevents graft-versus-host disease but spares graft-versus-tumor effects mediated by alloreactive CD8 T cells.lld:pubmed
pubmed-article:21779359pubmed:affiliationDepartment of Microbiology and Immunology, University of Maryland Medical School, Baltimore, Maryland, United States of America.lld:pubmed
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pubmed-article:21779359pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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