Linked Life Data

2175402

Source:http://linkedlifedata.com/resource/pubmed/id/2175402

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1991-1-28
pubmed:abstractText
The gamma-aminobutyric acid (GABA)-gated anion channel has been found to have a significant permeability to bicarbonate in isolated nerve cells and crayfish muscle. We have studied the extracellular pH of the in vitro turtle cerebellum to determine whether the extracellular pH of vertebrate brain can be modulated by GABA. Exposure to 10(-3) M GABA produced an extracellular alkaline transient with a mean amplitude of 0.054 +/- 0.19 pH units (n = 49, range 0.018-0.091 pH units). The GABA-evoked alkaline shift was blocked by picrotoxin and was dependent on the presence of HCO3- in the bathing media. These data suggest that GABAA receptors gate an HCO3(-)-efflux which is sufficient to modulate brain pH.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
A bicarbonate-dependent increase in extracellular pH mediated by GABAA receptors in turtle cerebellum.
pubmed:affiliation
Department of Neurosurgery, New York University Medical Center, NY 10016.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.