|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1978-1-27
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|
pubmed:abstractText |
Using the combination of alpha-L-arabinofuranosidase from Aspergillus niger with beta-peltatin A-alpha-L-arabinofuranoside, the selective effect of a new cancer of chemotherapy method based on a pH-dependent activation of cancerostatic prodrugs by exogenous enzymes was studied. In comparative experiments the selectivity of prodrug activation was measured by 3H-thymidine incorporation in tumor and normal tissues of CBA mice inoculated im with the transplantable mammary carcinoma, MA-21224. The results show that this special type of carrier principle may lead to a higher degree of selectivity than the usual direct application of cancerostatic drugs.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0361-5960
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1489-93
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:21745-Animals,
pubmed-meshheading:21745-Arabinose,
pubmed-meshheading:21745-Cyclophosphamide,
pubmed-meshheading:21745-DNA, Neoplasm,
pubmed-meshheading:21745-DNA Replication,
pubmed-meshheading:21745-Glycoside Hydrolases,
pubmed-meshheading:21745-Hydrogen-Ion Concentration,
pubmed-meshheading:21745-Mammary Neoplasms, Experimental,
pubmed-meshheading:21745-Mice,
pubmed-meshheading:21745-Mice, Inbred CBA,
pubmed-meshheading:21745-Podophyllotoxin
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|
pubmed:year |
1977
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|
pubmed:articleTitle |
Selective tumor DNA synthesis inhibition: in vivo prodrug activation by an exogenous enzyme.
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|
pubmed:publicationType |
Journal Article
|
