Linked Life Data

21741360

Source:http://linkedlifedata.com/resource/pubmed/id/21741360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-8-1
pubmed:abstractText
?-Dystroglycan (?-DG) plays crucial roles in maintaining the stability of cells. We demonstrated previously that the N-terminal domain of ?-DG (?-DG-N) is secreted by cultured cells into the culture medium. In the present study, to clarify its function in vivo, we generated a monoclonal antibody against ?-DG-N and investigated the secretion of ?-DG-N in human cerebrospinal fluid (CSF). Interestingly, we found that a considerable amount of ?-DG-N was present in CSF. ?-DG-N in CSF was a sialylated glycoprotein with both N- and O-linked glycan. These observations suggest that secreted ?-DG-N may be transported via CSF and have yet unidentified effects on the nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1090-2104
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
29
pubmed:volume
411
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Secretion of N-terminal domain of ?-dystroglycan in cerebrospinal fluid.
pubmed:affiliation
Department of Neurology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. f-saito@med.teikyo-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't