| pubmed-article:2173145 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C0027708 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2173145 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:2173145 | pubmed:issue | 4983 | lld:pubmed |
| pubmed-article:2173145 | pubmed:dateCreated | 1990-12-27 | lld:pubmed |
| pubmed-article:2173145 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173145 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173145 | pubmed:abstractText | The Wilms tumor locus on chromosome 11p13 has been mapped to a region defined by overlapping, tumor-specific deletions. Complementary DNA clones representing transcripts of 2.5 (WIT-1) and 3.5 kb (WIT-2) mapping to this region were isolated from a kidney complementary DNA library. Expression of WIT-1 and WIT-2 was restricted to kidney and spleen. RNase protection revealed divergent transcription of WIT-1 and WIT-2, originating from a DNA region of less than 600 bp. Both transcripts were present at high concentrations in fetal kidney and at much reduced amounts in 5-year-old and adult kidneys. Eleven of 12 Wilms tumors classified as histopathologically heterogeneous exhibited absent or reduced expression of WIT-2, whereas only 4 of 14 histopathologically homogeneous tumors showed reduced expression. These data demonstrate a molecular basis for the pathogenetic heterogeneity in Wilms tumorigenesis. | lld:pubmed |
| pubmed-article:2173145 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2173145 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173145 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2173145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2173145 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2173145 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:YegerHH | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:WilliamsB RBR | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:FeinbergA PAP | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:HuangAA | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:LawD JDJ | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:CampbellC ECE | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:BonettaLL | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:CoppesM JMJ | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:Chilton-MacNe... | lld:pubmed |
| pubmed-article:2173145 | pubmed:author | pubmed-author:McAndrews-Hil... | lld:pubmed |
| pubmed-article:2173145 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2173145 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:2173145 | pubmed:volume | 250 | lld:pubmed |
| pubmed-article:2173145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2173145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2173145 | pubmed:pagination | 991-4 | lld:pubmed |
| pubmed-article:2173145 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:2173145 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2173145 | pubmed:articleTitle | Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. | lld:pubmed |
| pubmed-article:2173145 | pubmed:affiliation | Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:2173145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2173145 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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