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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0017337,
umls-concept:C0032529,
umls-concept:C0032659,
umls-concept:C0035647,
umls-concept:C0140145,
umls-concept:C0152035,
umls-concept:C0684249,
umls-concept:C1158530,
umls-concept:C1332102,
umls-concept:C1335081,
umls-concept:C1366475,
umls-concept:C1707520
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pubmed:issue |
3
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pubmed:dateCreated |
2011-7-4
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pubmed:abstractText |
Reactive oxygen species (ROS) and numerous carcinogens may cause DNA damage including oxidative base lesions that contribute to the risk of lung cancer. The base excision repair (BER) pathway could effectively remove oxidative lesions in which 8-oxoguanine glycosylase-1 (OGG1), x-ray repair cross-complementing 1 (XRCC1), and apurinic/apyimidinic endonuclease 1 (APE1) play key roles. The aim of this study was to analyze the polymorphisms of DNA BER genes (OOG1, XRCC1 and APE1) and explore their associations, and the combined effects of these variants, with risk of lung cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-5487
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
226-34
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pubmed:meshHeading |
pubmed-meshheading:21722819-Adenocarcinoma,
pubmed-meshheading:21722819-Amino Acid Substitution,
pubmed-meshheading:21722819-Asian Continental Ancestry Group,
pubmed-meshheading:21722819-Carcinoma, Small Cell,
pubmed-meshheading:21722819-Carcinoma, Squamous Cell,
pubmed-meshheading:21722819-Case-Control Studies,
pubmed-meshheading:21722819-DNA Glycosylases,
pubmed-meshheading:21722819-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:21722819-DNA-Binding Proteins,
pubmed-meshheading:21722819-Female,
pubmed-meshheading:21722819-Gene Frequency,
pubmed-meshheading:21722819-Genetic Association Studies,
pubmed-meshheading:21722819-Genotype,
pubmed-meshheading:21722819-Humans,
pubmed-meshheading:21722819-Logistic Models,
pubmed-meshheading:21722819-Lung Neoplasms,
pubmed-meshheading:21722819-Male,
pubmed-meshheading:21722819-Middle Aged,
pubmed-meshheading:21722819-Multivariate Analysis,
pubmed-meshheading:21722819-Odds Ratio,
pubmed-meshheading:21722819-Polymorphism, Genetic,
pubmed-meshheading:21722819-Sequence Analysis, DNA,
pubmed-meshheading:21722819-Smoking
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pubmed:year |
2011
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pubmed:articleTitle |
Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population.
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pubmed:affiliation |
Department of Pathology, Third Military Medical University, Chongqing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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