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pubmed-article:21718840pubmed:abstractTextIncreased serotonin (5-hydroxytryptamine [5HT]) receptor (5HTR) signaling has been associated with cardiac valvulopathy. Prior cell culture studies of 5HTR signaling in heart valve interstitial cells have provided mechanistic insights concerning only static conditions. We investigated the hypothesis that aortic valve biomechanics participate in the regulation of both 5HTR expression and interrelated extracellular matrix remodeling events.lld:pubmed
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pubmed-article:21718840pubmed:copyrightInfoCopyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.lld:pubmed
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pubmed-article:21718840pubmed:articleTitleAortic valve cyclic stretch causes increased remodeling activity and enhanced serotonin receptor responsiveness.lld:pubmed
pubmed-article:21718840pubmed:affiliationThe Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.lld:pubmed
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