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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-7-1
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pubmed:abstractText |
Increased serotonin (5-hydroxytryptamine [5HT]) receptor (5HTR) signaling has been associated with cardiac valvulopathy. Prior cell culture studies of 5HTR signaling in heart valve interstitial cells have provided mechanistic insights concerning only static conditions. We investigated the hypothesis that aortic valve biomechanics participate in the regulation of both 5HTR expression and interrelated extracellular matrix remodeling events.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-6259
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-53
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:21718840-Animals,
pubmed-meshheading:21718840-Aortic Valve,
pubmed-meshheading:21718840-Biomechanics,
pubmed-meshheading:21718840-Blotting, Western,
pubmed-meshheading:21718840-Cell Proliferation,
pubmed-meshheading:21718840-Cells, Cultured,
pubmed-meshheading:21718840-Collagen,
pubmed-meshheading:21718840-Extracellular Matrix,
pubmed-meshheading:21718840-Fluoxetine,
pubmed-meshheading:21718840-Glycosaminoglycans,
pubmed-meshheading:21718840-Heart Valve Diseases,
pubmed-meshheading:21718840-Random Allocation,
pubmed-meshheading:21718840-Receptors, Serotonin,
pubmed-meshheading:21718840-Reference Values,
pubmed-meshheading:21718840-Regeneration,
pubmed-meshheading:21718840-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21718840-Sampling Studies,
pubmed-meshheading:21718840-Signal Transduction,
pubmed-meshheading:21718840-Stress, Mechanical,
pubmed-meshheading:21718840-Swine,
pubmed-meshheading:21718840-Tissue Culture Techniques,
pubmed-meshheading:21718840-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Aortic valve cyclic stretch causes increased remodeling activity and enhanced serotonin receptor responsiveness.
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pubmed:affiliation |
The Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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