Linked Life Data

217078

Source:http://linkedlifedata.com/resource/pubmed/id/217078

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1979-4-28
pubmed:abstractText
The effects of acrylamide intoxication were studied both in peripheral (PNS) and central (CNS) nervous system of rats. The animals were sacrified at different time intervals from the beginning of the intoxication. Histological and ultrastructural studies of peripheral nerves and long tracts of the spinal cord revealed a severe axonopathy, characterized by swelling of axons, particularly in the paranodal regions due to accumulation of neurofilaments with almost complete disappearance of neurotubules. There was also aggregation of dense bodies, swollen mitochondria and multivescicolar bodies in subaxolemmal regions. Presynaptic endings in the anterior horns of the spinal cord and in the cuneate nuclei were swollen and filled with packed filaments. Fiber degeneration at different stages was seen both in PNS and in CNS. These changes are not specific for acrylamide intoxication, having been observed in other experimentally induced neuropathies (n-hexane, Mn-BK, CS2, ...), as well as in a variety of diseases both genetically determined and due to exposure to toxic substances (glue-sniffing, leather cement poisoning, antiblastic therapy, ...). Accumulation of filaments in peripheral and central axons is the pattern of fiber degeneration characterizing the dying-back neuropathies. These axonal changes are particularly marked in the pacinian bodies as well as in the distal segments of the fibres. These data support the hypothesis that a dying-back neuropathy might depend on the direct effect of the toxic substance on the most vulnerable segments of the fibres, rather than on the perikaryon of the nerve cell, as previously supposed.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0035-6433
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-27
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
[Experimental neuropathy due to acrilamide. Histological and ultrastructural studies (author's transl)].
pubmed:publicationType
Journal Article, English Abstract