In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood. Here, we addressed the effects of AMPK activation/deletion on the activation of NF?B and determined whether the AMPK could contribute to the anti-inflammatory actions of nitric oxide (NO).
Nitric oxide-induced activation of the AMP-activated protein kinase ?2 subunit attenuates I?B kinase activity and inflammatory responses in endothelial cells.
