|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2011-7-6
|
|
pubmed:abstractText |
Aromatase inhibitors (AI) that inhibit breast cancer cell growth by blocking estrogen synthesis have become the treatment of choice for post-menopausal women with estrogen receptor positive (ER+) breast cancer. However, some patients display de novo or acquired resistance to AI. Interactions between estrogen and growth factor signaling pathways have been identified in estrogen-responsive cells as one possible reason for acquisition of resistance. Our laboratory has characterized an autocrine growth factor overexpressed in invasive ductal carcinoma named PC-Cell Derived Growth Factor (GP88), also known as progranulin. In the present study, we investigated the role GP88 on the acquisition of resistance to letrozole in ER+ breast cancer cells
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-10674872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-10682656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-10731103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-10760271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-11059787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-11134521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-11415996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-11457860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-11463858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-12586780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-12914763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-12928786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-12973694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-14652816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-14734490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-14996734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15117809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15489915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15701882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15814851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15860268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15867390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15958587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15967659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-15982868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-16885381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-17055257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-17169390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-19190349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-20530877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-21266779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-4688315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-7647336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-7784095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-8095168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-8764133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-8825123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-9056422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-9164678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21658239-9883986
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aromatase,
http://linkedlifedata.com/resource/pubmed/chemical/Aromatase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/GRN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/letrozole
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2407
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
231
|
|
pubmed:meshHeading |
pubmed-meshheading:21658239-Aromatase,
pubmed-meshheading:21658239-Aromatase Inhibitors,
pubmed-meshheading:21658239-Breast Neoplasms,
pubmed-meshheading:21658239-Cell Line, Tumor,
pubmed-meshheading:21658239-Cell Proliferation,
pubmed-meshheading:21658239-Cell Survival,
pubmed-meshheading:21658239-Down-Regulation,
pubmed-meshheading:21658239-Drug Resistance, Neoplasm,
pubmed-meshheading:21658239-Female,
pubmed-meshheading:21658239-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21658239-Gene Silencing,
pubmed-meshheading:21658239-Humans,
pubmed-meshheading:21658239-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:21658239-Nitriles,
pubmed-meshheading:21658239-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:21658239-RNA, Small Interfering,
pubmed-meshheading:21658239-Triazoles
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells.
|
|
pubmed:affiliation |
A&G Pharmaceutical Inc, 9130 Red Branch Rd, Columbia, MD, USA.
|
|
pubmed:publicationType |
Journal Article
|
