Linked Life Data

21653680

Source:http://linkedlifedata.com/resource/pubmed/id/21653680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2011-8-1
pubmed:abstractText
Tumor development relies upon essential contributions from the tumor microenvironment and host immune alterations. These contributions may inform the plasma proteome in a manner that could be exploited for cancer diagnosis and prognosis. In this study, we employed a systems biology approach to characterize the plasma proteome response in the inducible HER2/neu mouse model of breast cancer during tumor induction, progression, and regression. Mass spectrometry data derived from approximately 1.6 million spectra identified protein networks involved in wound healing, microenvironment, and metabolism that coordinately changed during tumor development. The observed alterations developed prior to cancer detection, increased progressively with tumor growth and reverted toward baseline with tumor regression. Gene expression and immunohistochemical analyses suggested that the cancer-associated plasma proteome was derived from transcriptional responses in the noncancerous host tissues as well as the developing tumor. The proteomic signature was distinct from a nonspecific response to inflammation. Overall, the developing tumor simultaneously engaged a number of innate physiologic processes, including wound repair, immune response, coagulation and complement cascades, tissue remodeling, and metabolic homeostasis that were all detectable in plasma. Our findings offer an integrated view of tumor development relevant to plasma-based strategies to detect and diagnose cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1538-7445
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5090-100
pubmed:meshHeading
pubmed-meshheading:21653680-Animals, pubmed-meshheading:21653680-Blood Proteins, pubmed-meshheading:21653680-Breast Neoplasms, pubmed-meshheading:21653680-Cell Line, Tumor, pubmed-meshheading:21653680-Disease Progression, pubmed-meshheading:21653680-Doxycycline, pubmed-meshheading:21653680-Female, pubmed-meshheading:21653680-Gene Expression Regulation, Neoplastic, pubmed-meshheading:21653680-Humans, pubmed-meshheading:21653680-Mammary Neoplasms, Experimental, pubmed-meshheading:21653680-Mammary Tumor Virus, Mouse, pubmed-meshheading:21653680-Mass Spectrometry, pubmed-meshheading:21653680-Mice, pubmed-meshheading:21653680-Mice, Transgenic, pubmed-meshheading:21653680-Neoplasm Proteins, pubmed-meshheading:21653680-Proteome, pubmed-meshheading:21653680-Rats, pubmed-meshheading:21653680-Receptor, erbB-2, pubmed-meshheading:21653680-Transgenes, pubmed-meshheading:21653680-Tumor Microenvironment
pubmed:year
2011
pubmed:articleTitle
Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression.
pubmed:affiliation
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural