Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1990-8-30
|
| pubmed:abstractText |
Thrombomodulin (TM) is a membrane protein in the vascular endothelium, and it plays an important role as a cofactor in the thrombin-catalyzed activation of protein C. It has also been found in human plasma; however, its clinical significance is not known. In this study, fasting plasma TM concentrations in 67 diabetic patients with different degrees of albuminuria (39 men aged 57 +/- 8 yr, 28 women aged 57 +/- 11 yr; means +/- SD) and 34 age- and sex-matched healthy subjects were investigated by use of a one-step sandwich enzyme immunoassay, a new method developed by H.I. and others. As a screening, the patients were divided into three groups according to the first morning urinary concentrations of albumin: group 1, less than 30 micrograms/ml (normoalbuminuria); group 2, 30-140 micrograms/ml (microalbuminuria); group 3, greater than 140 micrograms/ml (clinical nephropathy). There was no significant difference in plasma TM level between the control group (17.7 +/- 3.7 ng/ml, n = 34) and group 1 (16.9 +/- 3.4 ng/ml, n = 30); however, plasma TM concentrations in group 2 (22.8 +/- 3.4 ng/ml, n = 22) and group 3 (29.6 +/- 6.1 ng/ml, n = 15) increased significantly compared with those in the control group and group 1, respectively. As a further investigation, three timed overnight urine collections were made. The patients were allocated to three groups according to their rates of albumin excretion: group I, less than 20 micrograms/min (normoalbuminuria); group II, 20-200 micrograms/min (microalbuminuria); group III greater than 200 micrograms/min (clinical nephropathy).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
983-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2165005-Adult,
pubmed-meshheading:2165005-Aged,
pubmed-meshheading:2165005-Albuminuria,
pubmed-meshheading:2165005-Cell Membrane,
pubmed-meshheading:2165005-Cell Membrane Permeability,
pubmed-meshheading:2165005-Creatine,
pubmed-meshheading:2165005-Diabetes Mellitus,
pubmed-meshheading:2165005-Diabetic Angiopathies,
pubmed-meshheading:2165005-Diabetic Neuropathies,
pubmed-meshheading:2165005-Endothelium, Vascular,
pubmed-meshheading:2165005-Female,
pubmed-meshheading:2165005-Humans,
pubmed-meshheading:2165005-Male,
pubmed-meshheading:2165005-Middle Aged,
pubmed-meshheading:2165005-Receptors, Cell Surface,
pubmed-meshheading:2165005-Receptors, Thrombin
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Elevation of plasma thrombomodulin level in diabetic patients with early diabetic nephropathy.
|
| pubmed:affiliation |
Second Department of Internal Medicine, Asahikawa Medical College, Japan.
|
| pubmed:publicationType |
Journal Article
|