Source:http://linkedlifedata.com/resource/pubmed/id/21646476
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
2011-7-18
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| pubmed:abstractText |
Functionally polarized helper T cells (Th cells) play crucial roles in the induction of tumor immunity. There is considerable knowledge about the contributions of IFN-producing Th1 cells that supports the role of cytotoxic cluster of differentiation (CD8) T cells and natural killer (NK) cells, but much less is known about how IL-4-producing Th2 cells contribute to tumor immunity. In this study, we investigated the cellular and molecular mechanisms employed by memory Th2 cells in sustaining tumor immunity by using a mouse model system wherein ovalbumin (OVA) is used as a specific tumor antigen. In this model, we found that OVA-specific memory Th2 cells exerted potent and long-lasting antitumor effects against NK-sensitive OVA-expressing tumor cells, wherein antitumor effects were mediated by NK cells. Specifically, NK cell cytotoxic activity and expression of perforin and granzyme B were dramatically enhanced by the activation of memory Th2 cells. Interleukin 4 (IL-4) produced by memory Th2 cells in vivo was critical for the antitumor effects of the NK cells, which IL-4 directly stimulated to induce their perforin- and granzyme-B-dependent cytotoxic activity. Our findings show that memory Th2 cells can induce potent antitumor immunity through IL-4-induced activation of NK cells, suggesting potential applications in cellular therapy for cancer patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1538-7445
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| pubmed:author |
pubmed-author:EndoYusukeY,
pubmed-author:HashimotoKahokoK,
pubmed-author:ItoToshihiroT,
pubmed-author:KitajimaMasayukiM,
pubmed-author:MotohashiShinichiroS,
pubmed-author:NakayamaToshinoriT,
pubmed-author:NishimuraTakashiT,
pubmed-author:OnoderaAtsushiA,
pubmed-author:TumesDamon JDJ,
pubmed-author:YamashitaMasakatsuM,
pubmed-author:ZieglerSteven FSF
|
| pubmed:copyrightInfo |
©2011 AACR.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4790-8
|
| pubmed:meshHeading |
pubmed-meshheading:21646476-Animals,
pubmed-meshheading:21646476-Cell Growth Processes,
pubmed-meshheading:21646476-Cytotoxicity, Immunologic,
pubmed-meshheading:21646476-Immunologic Memory,
pubmed-meshheading:21646476-Immunotherapy, Adoptive,
pubmed-meshheading:21646476-Interleukin-4,
pubmed-meshheading:21646476-Killer Cells, Natural,
pubmed-meshheading:21646476-Lymphocyte Activation,
pubmed-meshheading:21646476-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:21646476-Mice,
pubmed-meshheading:21646476-Mice, Inbred BALB C,
pubmed-meshheading:21646476-Mice, Inbred C57BL,
pubmed-meshheading:21646476-Mice, Nude,
pubmed-meshheading:21646476-Mice, Transgenic,
pubmed-meshheading:21646476-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:21646476-Neoplasms, Experimental,
pubmed-meshheading:21646476-Th2 Cells
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells.
|
| pubmed:affiliation |
Department of Immunology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|