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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-8-23
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pubmed:abstractText |
The bisdioxopiperazine propane, ICRF-187, has been reported to potentiate doxorubicin cytotoxicity in certain tumor cell lines; however, the mechanism of this interaction is not known. In order to define the mechanism of this interaction, we examined the effects of ICRF-187 on doxorubicin cytotoxicity, free radical formation, and drug accumulation in human leukemia HL-60 cells. Studies show that ICRF-187 synergistically potentiated doxorubicin cytotoxicity in HL-60 cells. This potentiation of doxorubicin cytotoxicity by ICRF-187 appeared to result from enhanced drug dependent free radical formation without effecting doxorubicin uptake in HL-60 cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0955-3541
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2164412-Biological Transport,
pubmed-meshheading:2164412-Cell Line,
pubmed-meshheading:2164412-Cell Survival,
pubmed-meshheading:2164412-Daunorubicin,
pubmed-meshheading:2164412-Doxorubicin,
pubmed-meshheading:2164412-Drug Synergism,
pubmed-meshheading:2164412-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:2164412-Humans,
pubmed-meshheading:2164412-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:2164412-Piperazines,
pubmed-meshheading:2164412-Razoxane,
pubmed-meshheading:2164412-Stereoisomerism,
pubmed-meshheading:2164412-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Potentiation of doxorubicin cytotoxicity by (+)-1,2-bis-(3,5-dioxopiperazinyl-1-yl) propane (ICRF-187) in human leukemic HL-60 cells.
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pubmed:affiliation |
Biochemical Pharmacology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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