Linked Life Data

2164329

Source:http://linkedlifedata.com/resource/pubmed/id/2164329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-8-16
pubmed:abstractText
Low levels of [3H]-dihydroergocryptine (DHE) (alpha adrenergic receptor) binding to peripheral blood mononuclear leukocytes from asthmatic subjects were significantly increased following incubation with histamine. In contrast, [3H]-DHE binding was undetectable both before and after histamine incubation using cells from nonasthmatic subjects. The change in binding showed a biphasic dose dependence on histamine and was not associated with changes in DHA (beta-2 receptor) or yohimbine (alpha-2 receptor) binding. The induction of alpha adrenergic receptors by the ubiquitous inflammatory mediator histamine may help explain the alpha adrenergic hyperresponsiveness seen in asthmatic patients.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-4738
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects.
pubmed:affiliation
Department of Allergy and Clinical Immunology, Kaiser-Permanente Medical Center, Los Angeles, CA 90027.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't