Linked Life Data

21634415

Source:http://linkedlifedata.com/resource/pubmed/id/21634415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-6-24
pubmed:abstractText
Four new cyclic peptides, brachystemins F-I (1-4), and 11 known compounds were isolated from the aerial parts of Brachystemma calycinum. The absolute configurations of compounds 1-4 were assigned using Marfey's method. The structure of compound 5 was revised from cyclo(Pro¹-Phe²-Leu³-Ala?-Thr?-Pro?-Ala?-Gly?) to cyclo(Pro¹-Pro²-Ala³-Gly?-Leu?-Ala?-Thr?-Phe?) with QTOF/MS and X-ray diffraction analysis. The N-containing compounds were assessed for their inhibitory effects on the secretion of monocyte chemokine ligand 2 (CCL-2), interleukin 6 (IL-6), and collagen IV against high-glucose-stimulated mesangial cells. Compound 5 was evaluated for its effects on collagen I, reactive oxygen species (ROS), superoxide anion (O?(•?)) production, and cell viability in mesangial cells, and on nitric oxide (NO) production in macrophage cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1392-400
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Bioactive compounds from the aerial parts of Brachystemma calycinum and structural revision of an octacyclopeptide.
pubmed:affiliation
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't