| pubmed-article:21628465 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21628465 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:21628465 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:21628465 | lifeskim:mentions | umls-concept:C0252132 | lld:lifeskim |
| pubmed-article:21628465 | lifeskim:mentions | umls-concept:C1336636 | lld:lifeskim |
| pubmed-article:21628465 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:21628465 | pubmed:dateCreated | 2011-7-19 | lld:pubmed |
| pubmed-article:21628465 | pubmed:abstractText | Toll-like receptors (TLRs) modulate the expression of multiple microRNAs (miRNAs). Here, we report the down-regulation of miR-107 by TLR4 in multiple cell types. The miR-107 sequence occurs in an intron within the sequence encoding the gene for pantothenate kinase 1? (PanK1?), which is regulated by the transcription factor peroxisome proliferator-activating receptor ? (PPAR-?). PanK1? is also decreased in response to lipopolysaccharide (LPS). The effect on both miR-107 and PanK1? is consistent with a decrease in PPAR-? expression. We have found that the putative miR-107 target cyclin-dependent kinase 6 (CDK6) expression is increased by TLR4 as a result of the decrease in miR-107. This effect is required for increased adhesion of macrophages in response to LPS, and CDK6-deficient mice are resistant to the lethal effect of LPS. We have therefore identified a mechanism for LPS signaling which involves a decrease in miR-107 leading to an increase in CDK6. | lld:pubmed |
| pubmed-article:21628465 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21628465 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628465 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21628465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21628465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21628465 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21628465 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21628465 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:21628465 | pubmed:author | pubmed-author:O'NeillLuke... | lld:pubmed |
| pubmed-article:21628465 | pubmed:author | pubmed-author:BarbacidMaria... | lld:pubmed |
| pubmed-article:21628465 | pubmed:author | pubmed-author:SantamariaDav... | lld:pubmed |
| pubmed-article:21628465 | pubmed:author | pubmed-author:HennessyEliza... | lld:pubmed |
| pubmed-article:21628465 | pubmed:author | pubmed-author:SheedyFrederi... | lld:pubmed |
| pubmed-article:21628465 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21628465 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:21628465 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:21628465 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21628465 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21628465 | pubmed:pagination | 25531-9 | lld:pubmed |
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| pubmed-article:21628465 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21628465 | pubmed:articleTitle | Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. | lld:pubmed |
| pubmed-article:21628465 | pubmed:affiliation | School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. | lld:pubmed |
| pubmed-article:21628465 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21628465 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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