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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
2011-7-19
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pubmed:abstractText |
Toll-like receptors (TLRs) modulate the expression of multiple microRNAs (miRNAs). Here, we report the down-regulation of miR-107 by TLR4 in multiple cell types. The miR-107 sequence occurs in an intron within the sequence encoding the gene for pantothenate kinase 1? (PanK1?), which is regulated by the transcription factor peroxisome proliferator-activating receptor ? (PPAR-?). PanK1? is also decreased in response to lipopolysaccharide (LPS). The effect on both miR-107 and PanK1? is consistent with a decrease in PPAR-? expression. We have found that the putative miR-107 target cyclin-dependent kinase 6 (CDK6) expression is increased by TLR4 as a result of the decrease in miR-107. This effect is required for increased adhesion of macrophages in response to LPS, and CDK6-deficient mice are resistant to the lethal effect of LPS. We have therefore identified a mechanism for LPS signaling which involves a decrease in miR-107 leading to an increase in CDK6.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 6,
http://linkedlifedata.com/resource/pubmed/chemical/DEAD-box RNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/Dicer1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hif1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/MIRN107 microRNA, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Rela protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonuclease III,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/pantothenate kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1083-351X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25531-9
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pubmed:meshHeading |
pubmed-meshheading:21628465-Animals,
pubmed-meshheading:21628465-Cell Adhesion,
pubmed-meshheading:21628465-Cyclin-Dependent Kinase 6,
pubmed-meshheading:21628465-DEAD-box RNA Helicases,
pubmed-meshheading:21628465-Down-Regulation,
pubmed-meshheading:21628465-HEK293 Cells,
pubmed-meshheading:21628465-Humans,
pubmed-meshheading:21628465-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:21628465-Lipopolysaccharides,
pubmed-meshheading:21628465-Macrophages,
pubmed-meshheading:21628465-Mice,
pubmed-meshheading:21628465-MicroRNAs,
pubmed-meshheading:21628465-Myeloid Differentiation Factor 88,
pubmed-meshheading:21628465-PPAR alpha,
pubmed-meshheading:21628465-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:21628465-RNA, Messenger,
pubmed-meshheading:21628465-Ribonuclease III,
pubmed-meshheading:21628465-Time Factors,
pubmed-meshheading:21628465-Toll-Like Receptor 4,
pubmed-meshheading:21628465-Transcription Factor RelA,
pubmed-meshheading:21628465-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6.
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pubmed:affiliation |
School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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