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rdf:type |
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lifeskim:mentions |
umls-concept:C0021102,
umls-concept:C0030685,
umls-concept:C0220825,
umls-concept:C0279516,
umls-concept:C0391871,
umls-concept:C0439834,
umls-concept:C0680255,
umls-concept:C1143374,
umls-concept:C1283071,
umls-concept:C1522408,
umls-concept:C1697272,
umls-concept:C1704229,
umls-concept:C1704806,
umls-concept:C1705604,
umls-concept:C1963578
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pubmed:dateCreated |
2011-5-31
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pubmed:abstractText |
Madurahydroxylactone (MHL), a secondary metabolite with antibacterial activity was evaluated for its suitability to generate controlled drug release coatings on medical implant materials. A smooth and firmly attached layer could be produced from a precursor solution on various metallic implant materials. In physiological salt solutions these coatings dissolved within a time period up to one week. A combination of MHL with a broad spectrum fluoroquinolone antibiotic was used to create a coating that was active against all bacterial strains tested. The time period during which the coating remained active against Pseudomonas aeruginosa was investigated. The results indicated a delayed drug release from single layer coatings in the course of seven days. MHL was biocompatible in cell culture assays and could after a delay even serve as a cell adhesion substrate for human or murine cells. The findings indicate a potential for MHL for the generation of delayed release antimicrobial implant coatings.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-10555344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-10571905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-10656576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-10964299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-11071611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-11084852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-11567552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-12044378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-12676867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-12727914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-13686776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-1429755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-15175297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-15649408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-15697314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-15774886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-1611745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-16353112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-16651063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-16651073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-16651078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-1679802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-16953053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-17546021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-17918128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18336902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18405407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18431768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18720093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18814909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18820921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18974303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-18987019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19188775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19236181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19325879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19484769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19637369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19674778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19713519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19751126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19834595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19899620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-19943904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-20004967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-20102415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-259057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-362738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-3746628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-4601020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-5396594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-9177855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-9560093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21625377-9731279
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pubmed:language |
eng
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pubmed:journal |
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pubmed:status |
PubMed-not-MEDLINE
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pubmed:issn |
1874-1207
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pubmed:author |
pubmed-author:BadarMuhammadM,
pubmed-author:HauserHansjörgH,
pubmed-author:HemmenKatherinaK,
pubmed-author:LenarzThomasT,
pubmed-author:MöllmannUteU,
pubmed-author:MuellerPeter PPP,
pubmed-author:NimtzManfredM,
pubmed-author:SchnabelrauchMatthiasM,
pubmed-author:StieschMeikeM,
pubmed-author:StieveMartinM,
pubmed-author:VogtSebastianS
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-70
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pubmed:dateRevised |
2011-7-28
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pubmed:year |
2010
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pubmed:articleTitle |
Evaluation of madurahydroxylactone as a slow release antibacterial implant coating.
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pubmed:affiliation |
Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
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pubmed:publicationType |
Journal Article
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