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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-5-30
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pubmed:abstractText |
Elucidation of endogenous cellular protein-protein interactions and their networks is most desirable for biological studies. Here we report our study of endogenous human coregulator protein complex networks obtained from integrative mass spectrometry-based analysis of 3290 affinity purifications. By preserving weak protein interactions during complex isolation and utilizing high levels of reciprocity in the large dataset, we identified many unreported protein associations, such as a transcriptional network formed by ZMYND8, ZNF687, and ZNF592. Furthermore, our work revealed a tiered interplay within networks that share common proteins, providing a conceptual organization of a cellular proteome composed of minimal endogenous modules (MEMOs), complex isoforms (uniCOREs), and regulatory complex-complex interaction networks (CCIs). This resource will effectively fill a void in linking correlative genomic studies with an understanding of transcriptional regulatory protein functions within the proteome for formulation and testing of future hypotheses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-4172
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pubmed:author |
pubmed-author:BulynkoYaroslavaY,
pubmed-author:ChanDoug WDW,
pubmed-author:ChenRuiR,
pubmed-author:DingChenC,
pubmed-author:FuY PYP,
pubmed-author:JinS GSG,
pubmed-author:JungSung YunSY,
pubmed-author:KimBeom-JunBJ,
pubmed-author:KrenciuteGiedreG,
pubmed-author:LanzRainer BRB,
pubmed-author:LeNguyen TNT,
pubmed-author:LiChunshuC,
pubmed-author:MalovannayaAnnaA,
pubmed-author:O'MalleyBert WBW,
pubmed-author:VigPP,
pubmed-author:WangYiY,
pubmed-author:YucerNurN
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
787-99
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21620140-Amino Acid Sequence,
pubmed-meshheading:21620140-BRCA1 Protein,
pubmed-meshheading:21620140-Genome-Wide Association Study,
pubmed-meshheading:21620140-Humans,
pubmed-meshheading:21620140-Immunoprecipitation,
pubmed-meshheading:21620140-Mass Spectrometry,
pubmed-meshheading:21620140-Molecular Sequence Data,
pubmed-meshheading:21620140-Protein Interaction Mapping,
pubmed-meshheading:21620140-Proteins,
pubmed-meshheading:21620140-Proteome,
pubmed-meshheading:21620140-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:21620140-Transcription, Genetic
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pubmed:year |
2011
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pubmed:articleTitle |
Analysis of the human endogenous coregulator complexome.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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