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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-6-28
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pubmed:abstractText |
Insulin recruits muscle microvasculature, thereby increasing endothelial exchange surface area. Free fatty acids (FFAs) cause insulin resistance by activating inhibitor of ?B kinase ?. Elevating plasma FFAs impairs insulin's microvascular and metabolic actions in vivo. Whether salsalate, an anti-inflammatory agent, prevents FFA-induced microvascular and/or metabolic insulin resistance in humans is unknown.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1935-5548
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1634-8
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pubmed:meshHeading |
pubmed-meshheading:21617098-Emulsions,
pubmed-meshheading:21617098-Fatty Acids, Nonesterified,
pubmed-meshheading:21617098-Female,
pubmed-meshheading:21617098-Glucose Clamp Technique,
pubmed-meshheading:21617098-Humans,
pubmed-meshheading:21617098-Insulin Resistance,
pubmed-meshheading:21617098-Male,
pubmed-meshheading:21617098-Microcirculation,
pubmed-meshheading:21617098-Muscle, Skeletal,
pubmed-meshheading:21617098-Myocardium,
pubmed-meshheading:21617098-Phospholipids,
pubmed-meshheading:21617098-Salicylic Acids,
pubmed-meshheading:21617098-Soybean Oil,
pubmed-meshheading:21617098-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans.
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pubmed:affiliation |
Department of Internal Medicine, Division of Endocrinology and Metabolism, and the GeneralClinical Research Center, University of Virginia Health System, Charlottesville, Virginia, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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