Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1990-7-12
pubmed:abstractText
The gypsy retroposon of Drosophila melanogaster contains a sequence that potentiates upstream polyadenylylation sites. In contrast to other sequences that influence poly(A) site use, it appears to operate at the level of the DNA template. Nuclear extracts contained protein that bound to a repeated motif in the DNA. Flies with mutations that reduced transcripts polyadenylylated in the 5' long terminal repeat of gypsy contained less DNA-binding activity than wild type. A change in the repeat motif reduced both protein binding and poly(A) site potentiation. These findings provide evidence that DNA-binding proteins can regulate polyadenylylation sites.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-212715, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2462523, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2542128, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2579321, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2580642, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2601722, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2720783, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2836866, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2840337, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2849113, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2850261, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2866847, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-2987956, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3002632, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3014439, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3016512, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3017190, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3018490, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3018506, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3018551, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3023928, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3554233, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3568131, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3685975, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3779844, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3779845, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3779846, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-3936040, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-6246368, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-6269071, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-6275366, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-6300868, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-6329718, http://linkedlifedata.com/resource/pubmed/commentcorrection/2161539-822353
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4373-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Potentiation of a polyadenylylation site by a downstream protein-DNA interaction.
pubmed:affiliation
Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
pubmed:publicationType
Journal Article