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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-6-11
|
| pubmed:abstractText |
Highly purified human polymorphonuclear leucocyte collagenase cleaved human alpha-1-proteinase inhibitor (alpha 1-PI) at the carboxyl site of Phe352 (P7). The inhibitor was thereby rapidly inactivated and generated a primary degradation product as shown by reverse-phase HPLC and N-terminal sequencing. Prolonged incubation of the modified inhibitor with polymorphonuclear leucocyte collagenase led to the generation of a secondary degradation product with additional cleavage at the carboxyl site of Pro357 (P2).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
263
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
355-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2159425-Amino Acid Sequence,
pubmed-meshheading:2159425-Chromatography, High Pressure Liquid,
pubmed-meshheading:2159425-Humans,
pubmed-meshheading:2159425-Microbial Collagenase,
pubmed-meshheading:2159425-Molecular Sequence Data,
pubmed-meshheading:2159425-Neutrophils,
pubmed-meshheading:2159425-alpha 1-Antitrypsin
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Inactivation of human plasma alpha 1-proteinase inhibitor by human PMN leucocyte collagenase.
|
| pubmed:affiliation |
University of Bielefeld, Faculty of Chemistry, Department of Biochemistry, FRG.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|