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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-6-12
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pubmed:abstractText |
Silencer elements, by analogy to enhancer elements, function independently of their position and orientation. We show that the chicken lysozyme silencer S-2.4 kb has many other characteristics in common with enhancer elements. The silencer is comprised of modules that independently repress gene activity--repression being increased synergistically when different or identical modules are combined. Repression is effective both on a complete and on a minimal promoter consisting of a TATA box only. One silencer module is bound in vitro by a 75-93 kd protein, termed NeP1; the other can be bound either by the product of the oncogene v-erbA or by the thyroid hormone receptor. This erbA binding site is unusual in that the palindromic sequence is inverted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
505-14
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2159385-Animals,
pubmed-meshheading:2159385-Base Sequence,
pubmed-meshheading:2159385-Binding Sites,
pubmed-meshheading:2159385-Cell Line,
pubmed-meshheading:2159385-Cell Nucleus,
pubmed-meshheading:2159385-Chick Embryo,
pubmed-meshheading:2159385-Chickens,
pubmed-meshheading:2159385-Chromosome Deletion,
pubmed-meshheading:2159385-DNA-Binding Proteins,
pubmed-meshheading:2159385-Enhancer Elements, Genetic,
pubmed-meshheading:2159385-Genes, Regulator,
pubmed-meshheading:2159385-Macrophages,
pubmed-meshheading:2159385-Molecular Sequence Data,
pubmed-meshheading:2159385-Muramidase,
pubmed-meshheading:2159385-Oligonucleotide Probes,
pubmed-meshheading:2159385-Plasmids,
pubmed-meshheading:2159385-Proto-Oncogene Proteins,
pubmed-meshheading:2159385-Receptors, Thyroid Hormone,
pubmed-meshheading:2159385-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site.
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pubmed:affiliation |
Genzentrum, Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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